Journal S. salivarius is a spherical, Gram-positive, facultative anaerobic commensal bacterium that is both catalase and oxidase negative. Unlimited SDS Searches, 5 FREE Downloads, No Credit Card NAME: Streptococcus salivarius . SECTION I - INFECTIOUS AGENT . Thus, the bacterium is most often harmless but considered an opportunistic pathogen (1). The entire genome structure of a clinical strain CCHSS3 of S. salivarius was sequenced using the Sanger shotgun method to produce a draft of the genome, and Next Generation Sequencing was used to revise and correct any sequencing errors (4). Streptococcus salivarius. Domain: Bacteria Phylum: FirmicutesClass: BacilliOrder: LactobacillalesFamily: StreptococcaceaeGenus: StreptococcusSpecies: Streptococcus salivarius results in organisms entering into the blood stream COMMUNICABILITY: Not transferred from person-to-personDRUG SUSCEPTIBILITY: Sensitive to penicillin and erythromycin SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to many disinfectants - 1% sodium hypochlorite and 70% ethanol, formaldehyde, glutaraldehyde, iodines PHYSICAL INACTIVATION: Sensitive to moist heat (121° C for at least 15 min) and dry heat (160-170° C for at least 1 hour) SURVIVAL OUTSIDE HOST: Rim of drinking glass - at least 2 days; the organism has been isolated from the intestinal contents of housefliesSURVEILLANCE: Monitor for symptoms of infection; confirm bacteriologically and immunologically in acute stages FIRST AID/TREATMENT: Antibiotic therapy with penicillin (erythromycin for those sensitive to penicillin) PROPHYLAXIS: Monthly administration of benzathine penicillin or daily use of oral penicillin for those at greatest risk of infectionLABORATORY-ACQUIRED INFECTIONS: 78 recorded cases of Streptococcus spp. SYNONYM OR CROSS REFERENCE: Viridans streptococci . All rights reserved. Since food from the host enters the oral cavity, the amount of nutrients that S. salivarius, as well as other bacteria residing in the oral cavity, are essentially non-limiting. S. salivarius is a Gram-positive cocci so Gram stain results would show a purple stain under the microscope due to crystal-violet dye’s affinity to the thick peptidoglycan layer. There are three major reasons for the increase in number of genera that clinical microbiologist must identify. Streptococcus pyogenes: Systemic in respiratory tract, cause of infectious diseases (e.g. salivarius has been linked to cases of sepsis in people with neutropenia, a disease associated with a depleted level of white blood cells in the body (3). the Dually Regulated Class of Stress Response Genes in Gram-Positive Bacteria. Humans are introduced to S. salivarius within a few hours after birth, inhabiting the mouth and upper respiratory tract, making it one of the first commensal bacteria humans are exposed to (2). S. salivarius contains a peptidoglycan layer specifically called murein, which provides protection and rigidity, and helps shape the cell. It comprises of 2032 genes, with 2027 that encode for proteins; there are also 68 tRNA genes that encompass all the amino acids, and 6 rRNA operons (4). with 4 deaths up to 1976 SOURCES/SPECIMENS: Blood, throat cultures, sputum, respiratory secretions PRIMARY HAZARDS: Accidental parenteral inoculation CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment equipment and facilities for all activities involving known or potentially infected clinical materials or culture PROTECTIVE CLOTHING: Laboratory coat; gloves when contact with infectious materials in unavoidable SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill with absorbent paper towel and apply 1% sodium hypochlorite, starting at perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelledAlthough the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information.